Where do you live?  Maybe someone on here can suggest a doc in your area who doses meds more aggresively.  You can give both at the same time like Christine said, but for the most part, if the PPI is working properly and covering them as it should, they shouldn't really need both.  But it's worth a try.  Might also help with breakthrough at night.  There's an efferdose version of the zantac that tastes better, like citrus.  Not sure about the dosing of the zantac, but it also sounds quite low.

Hang in there.  Hopefully we can find you a doc that will help.

I'll try to look around for you here and on other forums and see if I can find a doc in your area.

As for the doctors saying that the meds aren't safe at high doses, it's because there hasn't been any formal research on the safety in children our age so many doctors go by adult dosing regimens which aren't set for infants.  Marci-kids has done research on the need for higher dosing, but of course, there haven't been studies that go back and look at kids that have been on these doses.  But the literature seems to suggest that it's safe, and even our ped GI, who is quite conservative, told me that it would be safe to keep Hailey on prevacid for her whole life if she needed to be.  There are some studies out there on the marci-kids site that you can reference to your new doc regardng the need for higher more frequent dosing in infants.  Or you can ask Dr. Phillips from marci-kids (who's a pharmacist) to call and talk to your doc.

The ped GIs and other docs don't know about these results because the marci-kids research has not been well disseminated.  I asked dr. Phillips about this recently and can't find his response, but basically he said that it takes 5 years or more to share results with the medical community due to standards for sharing research, or something like that.  Right now, most ped GIs follow the protocol set out by NASPHGAN (north american society of pediatric hepatology, gastroenteroly, and nutrition), and they don't have the results of marci-kids yet, due to the lag in information sharing apparently.  I recently also contacted them via email and phone and they wouldn't comment on this issue. I directed them to marci-kids website, but never heard anything back.

My feeling on the high dosing issue is that it's definitely a personal choice, and somewhat of a leap of faith.  But when you're already dealing with feeding problems, it's worth a try to see if that can help to control things.  Our feeding therapists have felt strongly that the pain has to be eliminated before they can even start feeding therapy.  Since you're still early in this journey, maybe things can be turned around.  High meds didn't help us, but they've helped others.  Good luck.