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October 24, 2006 at 9:14 am #16481
hellbennt
Keymasterhttp://www.nytimes.com/2006/10/24/health/24chil.html
ok I haven’t had time to read through it just yet-
but hopefully it ends better than where it starts

let’s discuss?
Ari is crying so I’ll get back to this later
~laura
October 24, 2006 at 9:40 am #16483Anonymous
InactiveLaura, thanks for posting, but really it doesn’t give you enough information to understand what kind of procedures they carried out to come to such a conclusion.
They say that they kept babies overnight and either gave “antireflux” drugs or no meds and “monitored” the reflux symptoms, of which they didn’t see a connection between the decreased symptoms and the meds at current doses. But what are antireflux meds? Is it a PPI or meds like zantac or reglan? Also, if it monitored by pH probe, then we know that these meds take up to weeks to kick in and show an improvement, so really an overnight admission with one night of meds would make no difference anyhow.
I really hate it when people publish such garbage. It just makes parents feels bad and question whether or not they are doing the right thing in medicating their child. It’s the same thing as when your mother or mother-in-law says “You call it acid reflux, but for us, that used to just be the way it was. There were no medications. Babies just spit up”. I want to smack people every time I hear that!
Anyhow thanks for sharing.
October 24, 2006 at 9:46 am #16484Anonymous
Inactive“The medicines, the study found, appeared to offer little if any benefit, at least at the current dosages”
I think that is the real key. If most doctors are still underdosing, of course they would have little or no benefit. It would be interesting to see what dosages the babies in the test were on, what meds they were on and how long they had been on it. I also like how they only kept the test patients overnight. Is that really long enough to determine if something is effective or not? I would love to read more about the test. Hopefully I can find something more online. If so, I will post it and others, please do the same.
Robin
October 24, 2006 at 9:47 am #16486Anonymous
InactiveLori:
Looks like we were responding at the same time and thinking about the same thing. Typical newspaper – just publish bits and pieces to cause a stir.
Robin
October 24, 2006 at 9:55 am #16487Anonymous
InactiveWhat a poorly designed study!!
One night of medication is not going to make a difference, and the doses were probably way too low anyway.The doc who designed this study is obviously of the mindset that it’s all in the mother’s head.
October 24, 2006 at 10:27 am #16488Anonymous
InactiveHere’s the link to the original source. Scroll down to number 9 and you’ll find the original data which was presented as a poster presentation at the North American Society of Pediatric Gastroenterology, Nutrition, and Hepatology.
Funny, because as expected, the article summarized in the NY times does not accurately depict the research findings… Gotta love the media.
Just thought I’d summarize that the researchers actually found a significant decrease in the number of GER episodes in the group who were on either PPI or H2 blockers compared to nothing. However, they found that when comparing PPI group to the H2 group, the H2 group had significantly more episodes of reflux, and the PPI group overall had fewer.
s&h’s mum2006-10-24 10:31:40
October 24, 2006 at 10:31 am #16489Anonymous
Inactivewell, the cinncinati hospital has a pretty good reputation for gastro problems. the article said the children were given a variety of reflux meds—-i would take that to mean H2 blockers and PPI’s were both probably used—and probably a few other meds as well.
my understanding is that the reason the PPI’s seem to take a little while to help is that it takes a couple of weeks for them to facilitate healing so that pain is eliminated—not that it takes a few weeks for the drug itself to start working in the body or “kick in” .i think that just about everyone of us on this board has said this—-but we are really passing on info to newcomers that is not exactly correct when we use those terms. the degree of esophageal irritation among different babies would explain why some babies get relief much quicker with PPi’s than other babies do.
the article didn’t state whether or not the infants were given medication for just that nights test, or if they had already been on the meds for an appropriate amount of time, nor did it tell the dosage amounts. it also didn’t tell what they were using to guage “relief”.
was it the babie’s apparent comfort level, or was it what a ph probe actually showed? there is just too much info missing to be able to make a good assessment of the study—-i wonder if the study could be looked up anywhere else that might give more details.
i know that when sylvia had her ph probe and endo done that she did not even flinch when she refluxed—-and her esophagus was ulcerated. you wouldn’t have known how bad her reflux was if you were just watching her behavior during the day. i actually thought she had a fairly good day the day of her probe. i guess what i am trying to say is that simply observing a baby on meds isn’t exactly “scientific”—-but i don’t know if that’s what they did during the study.
thanks for the link—you must havae posted the same time as i did—now i’ll go read about the study and see how far off i am in my assumptions!!LOL!!
kevieb2006-10-24 10:33:36
October 24, 2006 at 10:32 am #16490Anonymous
InactiveChristine, I just posted the link to the source data.
October 24, 2006 at 10:35 am #16491Anonymous
Inactivelori, i think we just keep missing each other on this thread!! i couldn’t get the link to work—can you double check it?
October 24, 2006 at 10:48 am #16493Anonymous
InactiveI can’t get the link to work either…
October 24, 2006 at 11:22 am #16494Anonymous
InactiveI’ll try it again. I’m not sure if you have to be a member to have special access, which might be why you can’t view it but when I click on the link, I can.
http://www.jpgn.org/pt/re/jpgn/pdfhandler.00005176-200610000 -00037.pdf;jsessionid=F2nTR9f1hDWcymYr9PGYpTFC0x6Ddh2hTsY6jW xJ4vMW37VJX55h!-1727789232!-949856145!8091!-1?index=11&d atabase=ppvovft&results=1&count=10&searchid=2&am p;nav=search
October 24, 2006 at 11:24 am #16495Anonymous
InactiveHere’s a summary that I was able to cut and paste in case you can’t view the link again. It’s also a summary, but summarized by the researchers, so you might get an idea of what they did:
EVALUATING EFFICACY OF ACID SUPPRESSION THERAPY IN INFANTS USING COMBINED pH-IMPEDANCE MEASUREMENT
[North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition Annual Meeting, October 19-22, 2006, Orlando, Florida: Abstracts: POSTER SESSION I, THURSDAY, OCTOBER 19, 2006, 5 p.m. – 7 p.m.: Esophagus/Stomach: 9]Kaul, Ajay; Campbell, William
Gastroenterology, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH.
Background:
There are currently no data on the efficacy of acid suppression therapy in infants.
Hypothesis:
Acid suppression therapy (at currently prescribed doses) in infants with suspected GERD, does not significantly alter the characteristics of GER events.
Methods:
We reviewed 30 consecutive pH-impedance data on infants 1 to 12 months (mean 3.8 months) suspected of having GERD over a 12 month period. The subjects were admitted overnight to record a minimum of 20 hours of continuous study using simultaneous pH-impedance testing. During the study, 15 subjects were fed via a nasogastric tube (continuous feeds) and 15 were fed orally. 13 were on a proton pump inhibitor (PPI, 0.5 to 1.5 mg/kg/day, 9 on H2-blocker (H2B, 2-6 mg/kg/day) and 8 on no acid suppression medications (No Meds).
Results:
In the orally fed group there was a trend towards more GER episodes recorded in subjects on acid suppression than those that were not (P = 0.09). Despite similar number of total reflux episodes, subjects on a PPI showed a trend towards less acid reflux episodes than those on H2B (P = 0.09). Subjects on a PPI had fewer proximal GER episodes than those on H2B or no medications but this was not statistically significant (P = 0.15). In the NG (continuous) fed group there were significantly fewer GER episodes noted than in the orally fed group (P = 0.03). Despite continuous NG feeds and acid suppression, the proportion of acid reflux episodes remained essentially unchanged. There were significantly fewer GER episodes in the group treated with either acid suppression regimen than those that did not (P = 0.04). Despite fewer GER episodes, the H2B treated group had a higher proportion of acid reflux episodes than those treated with a PPI. Subjects on PPI showed a trend towards fewer proximal GER episodes than those on H2B or no medications (P = 0.26).
Conclusions:
At the currently prescribed dosing regimen, our pilot data suggests that H2B have poor efficacy while PPI have borderline efficacy in the treatment of GERD in infants.
October 24, 2006 at 11:59 am #16497Anonymous
Inactiveit distinguishes between GER episodes and acid reflux episodes. does it tell anywhere what dosing regimen they used?
the results kind of explain why maybe some babies don’t seem to get relief even if they are on meds. reflux can be uncomfortable even when it is not painful because something just doesn’t feel “right”. it may be that some babies cry because they can feel the reflux, but are not in pain. it is their only way of telling us something feels wrong.
October 24, 2006 at 1:03 pm #16501Anonymous
Inactivekevieb wrote:
well, the cinncinati hospital has a pretty good reputation for gastro problems. the article said the children were given a variety of reflux meds—-i would take that to mean H2 blockers and PPI’s were both probably used—and probably a few other meds as well.
my understanding is that the reason the PPI’s seem to take a little while to help is that it takes a couple of weeks for them to facilitate healing so that pain is eliminated—not that it takes a few weeks for the drug itself to start working in the body or “kick in” .i think that just about everyone of us on this board has said this—-but we are really passing on info to newcomers that is not exactly correct when we use those terms. the degree of esophageal irritation among different babies would explain why some babies get relief much quicker with PPi’s than other babies do.
the article didn’t state whether or not the infants were given medication for just that nights test, or if they had already been on the meds for an appropriate amount of time, nor did it tell the dosage amounts. it also didn’t tell what they were using to guage “relief”.
was it the babie’s apparent comfort level, or was it what a ph probe actually showed? there is just too much info missing to be able to make a good assessment of the study—-i wonder if the study could be looked up anywhere else that might give more details.
i know that when sylvia had her ph probe and endo done that she did not even flinch when she refluxed—-and her esophagus was ulcerated. you wouldn’t have known how bad her reflux was if you were just watching her behavior during the day. i actually thought she had a fairly good day the day of her probe. i guess what i am trying to say is that simply observing a baby on meds isn’t exactly “scientific”—-but i don’t know if that’s what they did during the study.
thanks for the link—you must havae posted the same time as i did—now i’ll go read about the study and see how far off i am in my assumptions!!LOL!!
I have no idea how you guys do that little box thing to quote a portion of what someone said….but I wanted to say that what Christine says about it not actually taking two weeks for the meds to “kick in” makes sense. I know Prevacid worked right away for me even though I only took it ocassionally when I had reflux/heartburn during pregnancy. So, it makes sense also that some babies have more damage and that’s why it takes longer for them to get relief.
So, how do you create that little box to highlight just a portion of someone’s post? When I tried it it boxed the entire post, not what I meant to do.

ndrose2006-10-24 13:7:54
October 24, 2006 at 1:38 pm #16505hellbennt
Keymasterfirst you’ll see: bracket quote end bracket
then words
then
bracket /quote end bracket
you can edit the words inbetween
HTH
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