Some have done twice, some three times a day. It is hard, which is probably why they suggest zegerid or bufferbabies (don’t have to time around meals). You can always try twice daily and if that doesn’t work, then try the three times daily. Do your reasonable best with the timing of meals, and if you still don’t see an improvement, then maybe you can try with bufferbabies. We did three times daily, but we were using prevacid in caracream (the old bufferbabies). Good luck. 30mg often does the trick for a lot of little ones.