Brianna was MSPI but she was fine with teething tablets…I was told that it is the milk protiens, not the lactose (sugar) that most reflux babies react too. Good luck. I hope they provide some relief. WE use them before naps and bedtime when Brianna is teething. (she is a painfully slow teether…her top two teeth sat beneath the gums for two months before the finally broke through). They did seem to help her some.