Compounded Prilosec w/Grape Flavoring

[Anonymous]

Hello. I am new to infantreflux.org. I have a 2-month old grandson, Braydon, who is 2-months old and has severe acid reflux. He has been hospitalized twice already. He is finally seeing a GI Doc and he is being treated with Compounded Prilosec 2 x a day. For the first week or two my daughter had a very hard time getting him to take his medicine. That’s when the pharmacist mentioned that she could add the “grape flavoring”. Well, my daughter thinks that the Prilosec is not as effective now (after about 2 weeks) and says that Braydon is really refluxing again. He will reflux about 1 hour after he has had his bottle and then all of a sudden it just comes up. He then really cries and gets very fussy. Do any of you gals know if the “flavoring” does cause the prilosec to lose its effectiveness? Help

[Anonymous]

I’m going on memory here, so I could be wrong, but I believe that flavoring can decrease the effectiveness of a compound. Also, if it’s not compounded correctly, it becomes less effective after 2 weeks.

Welcome to the site!

[Anonymous]

Yes, it seems that adding flavouring to any of the compounded PPIs will degrade the drug so that it becomes ineffective within a few days to a week. According to marci-kids research, there are stability issues with compounded PPIs. They need to be made correctly with the right ingredients and the right amount of buffer, and then they will only be stable at the most for 2 weeks, I believe. A proper compound has no flavouring agents, and is made somewhere between 2-4mg/ml so that each dose has at least 3.5ml of medicine. If less than 7ml is given per dose, then the amount of buffer should be at least 16.8 percent sodium bicarbonate, and if more than 7mls, it can be half that. Since your grandson is taking prilosec, compounding it properly makes it exactly like the drug zegerid. This drug was initially developed by marci-kids based on their research. It is basically a stable version of a prilosec suspension, so you don’t have to worry about it being compounded. You can go to http://www.marci-kids.com for more details. Another possiblity is that his dose isn’t high enough. Marci-kids suggests higher and more frequent dosing of PPIs, which is kind of untraditional compared to what most docs prescribe. Good luck in helping your grandson… what a good grandma!

[hellbennt]

welcome!

I’ve written/provided info ALL about this here- scroll down to the purple post called ‘prevacdi 101’ (the first post is also very important but I didn’t post it– read that too!)

https://www.infantreflux.org/forum/forum_posts.asp?TID=6026&a mp;PN=1

your daughter is one observant mama!!

~laura

[Anonymous]

This is the link that explains EXACTLY how to compound the PPI . you have to show it to the pharmacist.

copy and paste this link in your browser:

https://www.infantreflux.org/forum/forum_posts.asp?TID=4505 &KW=ppi

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