I know, Natalia, it doesn’t really make much sense.
Yeah, an overall greater amount of solution per dose would equal more mls of meds (especially when it’s a different concentration), but I don’t know how they can just recommend giving more b/c you need more buffer. Shouldn’t the recommended amount per day be based on how the med is metabolized?
My understanding is that when using the 20mg packets, you’re fine b/c you have enough buffer as long as each dose is 3.5ml. Does that mean that when using the 40mg packets (not with the mylanta) each dose needs to be 7ml or more to ensure enough buffer? If so then the dosing would need to be high per day for it to work.
The only thing that I can make of what he said is that they had to actually suggest higher dosing if using the 40mg packets (without the mylanta) in infants, because each dose would need to be at least 7ml to ensure enough buffer per dose (due to 7.4 percent sodium bicarb in 40mg packs vs twice as much in the 20mg packs). When recommending how much to give using the 20mg packets, they used the pharmacokinetics curve based on omeprazole, but it sounds like when recommending using the 40mg packets, they had to suggest higher values to make sure that each dose would be 7ml. That would up the total number of recommended mgs per day. (Gee, I think that’s as confusing as his reply! Not even sure if I can understand my own thought process! Anyhow, I’m just guessing that’s what he was trying to say).
Essentially, the way it was described to me, is that the 20mg packets (and the CaraCream JR kits) are like a stable solution made at 2mg/ml and 16.8 percent sodium bicarbonate. The 40mg packets (and the regular CaraCream kits) are like a stable solution made at 4mg/ml and I thought half the amount of sodium bicarbonate.
Anyhow, I guess I should just let it go, but it’s become almost like a riddle to me, LOL.
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Just let me know.
