Hmmm, every baby is different but unfortunately it’s kind of a trial and error thing trying to figure out meds. It was with us anyway. If your baby is having a lot of trouble at night, try giving a dose right before bed. Kate gets three doses a day and one right before bed b/c early morning feeds were always sort of a toughy for us. How many doses are you giving? For us,and a lot of other kiddos,it really helps to break up the doses just b/c babies metablize meds so much faster and need it more often than us. I hope some of this helps but I’m sure other mamas will have more information and great things to say. Good luck with it. I hope you figure it out soon!!